Introduction: This study aimed to predict symptoms of depression based on cognitive flexibility, rumination and mindfulness of students. Method: This design of current study was of descriptive correlational type. The study population consisted of all students enrolled in 2014-2015 school year in Tabriz Azad University, among which 180 were selected by random cluster sampling. Subjects completed cognitive flexibility Inventory (CFI), the Beck Depression Inventory 2 (BDI-II), rumination (RRS) and the Freiburg Mindfulness Inventory. Multiple regression analysis was used to analyze the data. Results: The results showed that there is a significant negative correlation between cognitive flexibility and its subsets with depression (P<0.001), and there was a significant positive correlation between rumination and depression (P<0.001). The relationship between mindfulness and depression was significant and negative (P<0.001). The results of regression analysis showed that these variables explain 57% of depression. Discussion: The results of this study have therapeutic implications based on Cognitive Flexibility Training through cognitive behavioral therapy, as well as Mindfulness Training, on rumination reduction and depression symptoms.

Keywords: Cognitive flexibility, Rumination, Mindfulness, Depression.

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