Volume 13, Issue 1 (7-2026)
Shenakht Journal of Psychology and Psychiatry 2026, 13(1): 97-111 |
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Ebadi M, Narimani M, Aghajani S, Eyni S, Fattahzadeh Ardalani G. Is Oxidative Stress a Hidden Factor in Cognitive Deficits in Children with specific Learning disorder: A Systematic Review.. Shenakht Journal of Psychology and Psychiatry 2026; 13 (1) :97-111
URL: http://shenakht.muk.ac.ir/article-1-2541-en.html
URL: http://shenakht.muk.ac.ir/article-1-2541-en.html
Matine Ebadi1 
, Mohammad Narimani *2 , Seyfollah Aghajani1 , Sanaz Eyni1 , Ghasem Fattahzadeh Ardalani1
, Mohammad Narimani *2 , Seyfollah Aghajani1 , Sanaz Eyni1 , Ghasem Fattahzadeh Ardalani1
1- University of Mohaghegh Ardabili
2- University of Mohaghegh Ardabili ,mohammadnarimani.uma.ac@gmail.com
2- University of Mohaghegh Ardabili ,
Abstract: (13 Views)
Introduction: Children with learning disorders show memory and language deficits that may be related to oxidative stress.
Objective: The aim of the present study was to investigate the possible relationships between cognitive deficits and oxidative stress markers in children with specific learning disorders through a systematic review.
Method: The present study was a systematic review. The search period for articles in Persian and English was from the beginning of 2000 to the end of May 2025, which was conducted in databases (Science Direct, SID, WOS, PubMed, Scopus) and the Google Scholar search engine. During the review process, the following keywords were used: ("oxidative stress"), ("cognition" or "cognitive disorder"), ("learning disorder" or "dyslexia" or "mathematical learning disorder"), and "antioxidant". Finally, 7 relevant articles were selected based on the inclusion and exclusion criteria and were reviewed and analyzed.
Results: The findings showed that in total, 564 individuals with SLD were compared with 596 normal individuals. A total of 9 oxidant biomarkers and 9 oxidant-related biomarkers were examined. Among oxidants, MDA was studied 3 times, and in all 3 cases it was higher in the SLD group. The antioxidant biomarkers GPx, SOD, and CoQ10 were each examined twice, and in all cases, the findings showed that the SLD group had lower values than normal individuals. Results regarding the association between oxidative stress-related indices and intelligence and test scores related to SLD were inconsistent.
Conclusion: The results indicate that some indicators of oxidative stress may be significantly associated with cognitive and learning performance in children with learning disorders. Therefore, it is better to further investigate these indicators so that they can be used as valid criteria for evaluating treatment, diagnosis, or even the severity of SLD.
Objective: The aim of the present study was to investigate the possible relationships between cognitive deficits and oxidative stress markers in children with specific learning disorders through a systematic review.
Method: The present study was a systematic review. The search period for articles in Persian and English was from the beginning of 2000 to the end of May 2025, which was conducted in databases (Science Direct, SID, WOS, PubMed, Scopus) and the Google Scholar search engine. During the review process, the following keywords were used: ("oxidative stress"), ("cognition" or "cognitive disorder"), ("learning disorder" or "dyslexia" or "mathematical learning disorder"), and "antioxidant". Finally, 7 relevant articles were selected based on the inclusion and exclusion criteria and were reviewed and analyzed.
Results: The findings showed that in total, 564 individuals with SLD were compared with 596 normal individuals. A total of 9 oxidant biomarkers and 9 oxidant-related biomarkers were examined. Among oxidants, MDA was studied 3 times, and in all 3 cases it was higher in the SLD group. The antioxidant biomarkers GPx, SOD, and CoQ10 were each examined twice, and in all cases, the findings showed that the SLD group had lower values than normal individuals. Results regarding the association between oxidative stress-related indices and intelligence and test scores related to SLD were inconsistent.
Conclusion: The results indicate that some indicators of oxidative stress may be significantly associated with cognitive and learning performance in children with learning disorders. Therefore, it is better to further investigate these indicators so that they can be used as valid criteria for evaluating treatment, diagnosis, or even the severity of SLD.
Type of Study: Research |
Subject:
Special
Received: 2025/06/9 | Accepted: 2025/06/18 | Published: 2026/06/22
Received: 2025/06/9 | Accepted: 2025/06/18 | Published: 2026/06/22
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