Introduction: Obsessive Compulsive Disorder has been comorbid with several disorder, it accompanies serious problems and deficiencies in the working lives of those afflicted with it. Aim:The purpose of this study was conducted the effectiveness of Schema therapy on modification early maladaptive schemas patient with resistent Obsessive-Compulsion disorder (OCD). Method: Populator statistical include all individual , patient with resistent OCD, on year 1392 referring were center psychiatrist-psychology Arak city.For this purpose, in a quasi- experimental study pre-test and post-test with control group, 24 subjects resistent (OCD) were selected via convenient sampling which randomly assigned into experimental and control groups. Subjects were assessed for early maladaptive schemas, both before and after the treatment.The experimental group had received twenty session of schema therapy approach . To assess the schema using SCHEMA QUESTION and YOUNG PARENTING INVENTORY. The applied intervention was evaluated in three stages: pretest, post-test and one month follow-up. Data were analyzed by of Repeated measurement and Graphical Diagram. Results: The Results of present study showed severity of Schema dominant decreased The significantly in the experimental group than the control group (p=0.001). Conclusion:It appears that Schema therapy with applying Techniques Cognition, Experiential, and also unique therapeutic alliance, could be effective for reducing the severity Schema dominant of resistent Obsessive-Compulsion disorder (OCD).